Cognitive behaviour therapy (CBT) has rarely been offered to students seeking professional psychological help at universities in the UK. Here, we aimed to investigate whether a brief course of CBT would improve anxious and depressive symptoms. Forty-eight student patients received a brief course of CBT at a university National Health Service, Student Health Centre in England. Patients completed weekly self-report measures of anxiety and depression at the commencement of each CBT session. Student patients receiving CBT showed significant decreases in anxiety and depression. These effects remained after controlling for a range of potential covariates (e.g. primary problem, total time in treatment, therapist qualifications). Findings suggest CBT is effective in reducing anxiety and depressive symptoms in a ‘real-world’ university clinic.